Solutions

Chemical synthesis needs to evolve and adapt to the challenges of the future, and free itself from the restraints of laborious and time-consuming processes. New technologies must strive to provide safe, effective and productivity enhancing solutions. Our new automated capsule based synthesiser addresses all these issues and more!
 
The small and compact capsule-based synthesizer for the generation of research products, works in an analogous manner to a capsule coffee maker. Simply add the starting material to be transformed and a commercially available, single-use, disposable reagent capsule and with a single touch of a button, the product is generated, isolated and purified!
 
Following the generation of the desired product, an automated washing sequence allows the machine to be used directly by another user without risk of contamination. With all the chemicals and solvents required for the transformation, as well as the waste generated, the risk of user exposure is drastically reduced. Thus this technology offers not only time-saving, productivity, and efficiency benefits, but it offers a far safer process than the respective traditional synthetic procedure.
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The 3 in 1 solution offers an unprecedented combination of hardware, software and an optimized chemical process. Use of the automated synthesizer, in conjunction with the specialised capsules, offers the opportunity to break free of the limitations imposed by traditional synthesis, and the benefits of a safe, time-efficient, cost effective, plug and play synthetic procedure.

How does Synple work?

Settings up a reaction on Synple 2

Comparison of Synple 1 vs manual synthesis

How can Synple help me?

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5x more efficient

Much less working time is required to generate new molecules. The synthesizer will only take 5-10 minutes to set up and will run completely autonomously. This offers the potential to increase the productivity of every synthetic chemist, whatever level of skill and experience.
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No training required - Easy to use

The plug&play device is intuitive to use and requires no special training. No detailed chemistry knowledge is necessary to create new molecules.

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70% Lower costs

Compared to carrying out a reaction manually, the synthesizer can cut down on 70% of the costs to generate one molecule.

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High Safety

The automatic reactor is fully enclosed, thus the user has no exposure to any chemicals used during the synthetic process. This complies with newest laboratory safety standards.

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Small footprint

With only 25 x 35 cm footprint, the synthesizer uses only a minimum amount of space and fits in every laboratory.
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90% less waste

The fully optimized reaction sequence uses only a minimum amount of reagents and solvents, therefore reducing overall waste.

Testimonials from Synple Users

We are working with the Synple instrument in our laboratory for several months now
The first reaction tested was the one using SnAP reagents. The interest of this reaction developed by Professor BODE to form original saturated heterocycles was presented to us at a medicinal chemistry symposium a few years ago.
We then purchased the corresponding SnAP reagents sold by Aldrich and tested them under conventional laboratory conditions with original aldehydes and ketones. Although the results were satisfactory, the perspective of using potentially toxic products such as tin derivatives was not very encouraging. This very simple to use synthesizer has not only avoided handling these reagents but also improved the efficiency of the reaction by leading to often clean products with good yields.
Applied to reductive amination reactions, the same technology has led to variable results, more or less satisfactory depending on the type of amines used (salified, primary or secondary).
Two very convincing tests were also carried out on the formation of PROTACs from aldehyde and appropriate pre-filled cartridge.
Ease of use, reproducibility of experiments and non-exposure to toxic chemical substances are the major assets of this new automated synthesizers, which should be developed in particular to support scale-up.

As a beta-tester I have successfully used Synple’s technology for all its existing applications. The N-heterocycle forming application is easy to use and I would much rather use this machine to do SnAP chemistry then do the reaction in a flask. The reductive aminations also work well and the PROTAC application is a great way forward for this technology!

We have had the Synple instrument in our labs for several months now. We like the instrument and it works perfectly well. We have found that anyone can get good results with the SnAP cartridges without first having to learn the insights of SnAP through painful failures. The same chemistry on the same scale was far better on the instrument than it was in the flask.
The reductive alkylation of secondary amines was successfully achieved using paraformaldehyde and small amine fragments, resulting in water soluble products. The instrument gave the product in good quantity and initial quality. Although the final products did need some further purification, our chemists struggled to reach the same level of quantity and purity when the reaction was performed in a flask.
In summary, the instrument really makes life easier and, especially if there were a way to scale up the reactions in a similarly easy way, then I wouldn’t want anyone in my organization to perform the SnAP and reductive alkylation reactions in the traditional way. Just adding the reagents and then pressing the button is so much easier and reproducible.

Available reaction classes

N-Heterocycle formation

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Our first, currently available reaction class facilitates the generation of N-Heterocycles. These include morpholines, piperazines, oxazepanes, diazepanes and more complex spiro and bicyclic structures. A broad scope of structurally and electronically different aldehydes can be readily transformed to the N-heterocycle in a very easy manner following just a 10 min reaction setup.
  • 10 different Heterocycle structures currently available
  • Scale: up to 0.5 mmol
The cartridge contains all reagents and catalysts for the imine formation, cyclisation and purification.
Advantages compared to classical batch chemistry are:
  • Minimise user exposure to toxic tin reagents
  • Multistep reactions completed at the touch of a button
  • High reproducibility
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What is in the heterocycle formation cartridges:

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Reductive Amination

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The second reaction class currently enables a reductive amination process. A larger number of complex amines can be generated easily from aldehydes or ketones and primary or secondary amines. 
The cartridge contains all reagent for the condensation, reduction and purification steps of the process.
  • Scale: up to 0.5 mmol
Advantages compared to classical batch chemistry are:
  • Time-saving – reaction, work up and purification in a single process
  • Automation of routine chemistry to allow more time for technically demanding reactions
  • Generic methods, selected based on reaction partners, minimize need for reaction optimization.

 

What is in the reductive amination cartridges:

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Mitsunobu Reaction

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Since its discovery in 1967, Mitsunobu reaction has got a privileged role in organic synthesis and medicinal chemistry because of its scope, stereoselectivity and mild reaction conditions. Its ability of easily forming carbon-carbon bond through dehydrative coupling of a primary or secondary alcohol with a pronucleophile is sometimes counterbalanced by the formation of byproducts which can plague purification strategies. With the Synple machine Mitsunobu reaction can be run without these drawbacks.
  • Scale: up to 0.5 mmol
  • Applicable to a range of pronucleophiles (phenols, phthalimides, tosylamides, tosylhydrazones).
Avantages compared to classical Mitsunobu batch chemistry are:
  • Only 5-10 working time required to obtain Mitsunobu product.
  • No tedious removal PPh3O necessary.

What is in the Mitsunobu cartridges:

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PROTAC formation

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The third reaction class enables the formation of PROTACs. Both VHL and CRBN Ligands are available with different lenghts of PEG linkers.
The cartridge contains all reagents for the linking the carbonyl group of a protein binder with the partial PROTAC and components for the purification steps of the process.
  • Scale: up to 0.1 mmol
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What is in the PROTAC cartridges:

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Biotin Tags

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Biotin Tags

The fourth reaction class enables the attachemnt of Biotin tags to amines and aldehydes/ketones. Different lenghts of PEG linkers are available. 
The cartridge contains all reagents for the linking the compound of choise to a variety of biotin tags and also includes components for a simple purification step.
  • Scale: up to 0.1 mmol
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What is in the Biotin cartridges:

For Amine-Linker
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For Amide-linker
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Deoxyfluorination

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Boc Protection

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Boc protection

N-Boc protections are one of the most widely used protection groups used in synthetic chemistry.
The Synple Chem synthesizer offers an easy and fast automated method to Boc-protect
primary and secondary amines with less than 5 min working time and no left-over Boc-Anhydride.
  • Scale: two sizes available; up to 0.5 mmol and up to 1.2 mmol

What is in the Boc protection cartridges:

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Boc Deprotection

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Boc deprotection

What is in the Boc deprotection cartridges:

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Azide formation

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Details about two reaction classes can be found in our recent poster:
Are you looking for another chemistry application? Contact us!

You want to know more?

Frequently Asked Questions

Who is Synple Chem?

Snyple Chem was founded in 2016 as a Spin-off from ETH Zürich. Our mission is to provide easy to use, safe, efficiency-enhancing solutions that represent the future of organic synthesis. 
 

How many products are on the market?

Now, alongside the Synple 1 and 2, we have our latest addition - the Synple Unity, a flexible parallel synthesiser.
 

Can I put my own materials in the cartridges?

No, the cartridges come ready filled with all the reagents and materials required for the reaction, work-up and purification. We can, however, provide custom cartridges for users under certain circumstances.
 

What solvents are compatible with the machine?

The machine itself is tolerant of almost all solvents. The limitation are only related to what is tolerated in terms of the chemistry by each reaction class. More information can be found in our application notes.
 

How does the machine handle poorly soluble starting materials?

In many cases, co-solvents can be added to help solubiulise poorly soluble starting materials. 
 

How are lower reacting starting materials handled?

We provide a scope for each reaction that indicates what is fast reacting and slow reacting. For slower reacting materials we recommend increasing the default reaction time. 

Can I run more than one reaction at the same time?

With the Synple 1 and Synple 2, only one reaction can be run at a time. The Synple Unity system allows you to build a parallel synthesis system to suit your own needs.
 

How much maintenance is required?

The machine requires very little maintenance and most of the components, e.g. the lines, connections, vial, are all standard. We are also able to offer service and maintenance contracts.
 

Do you have products on the market?

Yes! Our Synple 1 machines have been installed with customers since May 2018 and our new Synple 2s have been in use since October 2019.
 

In which countries is Synple available?

At the moment we sell directly across Europe and the UK. We can also sell direct in the US or alternatively use a distributor. In addition, we are in discussions with several distributors across Asia.
 

What is the lead time for the machine and cartridges?

The average lead time for the machine is four weeks. Cartridges can be delivered within the week.

Can my starting material be dissolved in a broad range of solvents?

This depends on the reaction class and what is tolerated by each particular reaction. In many cases co-solvents can be used to help solubilise the starting material.
 

Does the machine allow for reaction monitoring?

Each method has been pre-optimised to give the best yield and purity across a broad substrate scope. If optimisation is required then we would recommend skipping the purification step and checking the product at the end of the run. If it has not gone to completion, the reaction can be run again.
 

Can the machine be connected to analytical or purification systems?

This is something we are actively exploring.

How long does a run take?

This is dependant on the reaction class. Each run time includes the reaction, work-up and purification time.
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